Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications
Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications / Saji Uthaman, Kang Moo Huh, In-Kyu Park
p. 172-182 ; 30cm
수록자료: Biomaterials research : the official journal of the Korean Society for Biomaterials. Korean Society for Biomaterials. Vol.22 no.3(2018 September), p. 172-182 22:3<172 ISSN 1226-4601↔ 저자: Saji Uthaman, Department of Polymer Science and Engineering, Chungnam National University 저자: Kang Moo Huh, Department of Polymer Science and Engineering, Chungnam National University 저자: In-Kyu Park, Department of Biomedical Sciences, BK21 PLUS Centre for Creative Biomedical Scientists, Chonnam National University Medical School
Background: Cancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating cancer cells to evade or defend conventional anti-cancer therapy such as surgery, chemotherapy and radiotherapy. One of the most important challenges in the development of anti-tumor therapy is the successful delivery of therapeutic and imaging agents specifically to solid tumors. Main body: The recent progresses in development of TME responsive nanoparticles offers promising strategies for combating cancer by making use of the common attributes of tumor such as acidic and hypoxic microenvironments. In this review, we discussed the prominent strategies utilized in the development of tumor microenvironment-responsive nanoparticles and mode of release of therapeutic cargo. Conclusion: Tumor microenvironment-responsive nanoparticles offers a universal approach for anti-cancer therapy.